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柴 卓

作者: 柴卓     发布时间: 2019-11-20 点击数:

     


     

 

卓(教授,博士生导师(shi))

爱(ai)游戏(xi)app 应(ying)用化学系

ORCID: http://orcid.org/0000-0002-9878-8814

教育(yu)经历(Education)

1999920037           安徽(hui)师范大(da)学          化学(xue)专业      理学学士

2003920087   中国科学院上海有(you)机化学研究所(suo)  有机化(hua)学(xue)专业    理学博士

工(gong)作(zuo)经历(li)(Research experience)

20082009     中(zhong)国(guo)科学院上(shang)海有机化(hua)学研(yan)究所(suo)                    助(zhu)理研究(jiu)员

20092011     Montana State University (USA)                          博士(shi)后

20112012     Université de Rouen et INSA de Rouen (France)             博(bo)士(shi)后

2012年至今        安徽师(shi)范(fan)大学爱(ai)游(you)戏app        讲(jiang)师,副教授,教授(20177月起)

主(zhu)持项目(Funding)

6. “生(sheng)物活性分(fen)子合成(cheng)导向的(de)外消旋(xuan)吖丙(bing)啶不对称(cheng)催化转化研究”,国家自然(ran)科(ke)学基金面上项目(21971003),直(zhi)接(jie)经费: 65万元,2020年1月–2023年12月。

5. “钯(II)-Brønsted acid-亚磷酸(suan)酰胺(an)体(ti)系在氧(yang)化(hua)性(xing)反应(ying)条(tiao)件下(xia)的不对称协(xie)同催(cui)化(hua)应(ying)用研(yan)究”,国家自然科学(xue)基金面上项目(21472001),84万(wan)元,2015年1月–2018年12月。

4. “烯(xi)烃(ting)化(hua)合(he)物的不(bu)对称串(chuan)联(lian)亲电加成–成环(huan)反应研究”,国家自然科学基金青年基金项(xiang)目(21202001),25万(wan)元,2013年1月(yue)(yue)–2015年12月(yue)(yue),已结题。

3. “基于不(bu)对(dui)称(cheng)亲电反应的毒扁豆碱类生物(wu)碱的合成研究”,安(an)徽省自(zi)然科学基金面上项目(1308085MB17),5万元,2013年7月–2015年6月,已(yi)结题。

2. “基(ji)于不对称亲电反(fan)应(ying)的(de)吡咯并吲哚啉类(lei)生物碱(jian)的(de)合(he)成(cheng)研究”,中科院天然产物重点实验(yan)室(shi)开放(fang)基(ji)金项(xiang)目,3万元,2012年(nian)12月–2014年(nian)12月,已结题。

1. 安(an)徽师范大学博士科研启动基金(jin),2万(wan)元。

讲授课程(Courses)

1.《精(jing)细有机(ji)合成》

2. 基础(chu)/综合化学(xue)实验

研(yan)究兴趣(Current Research Projects)

不对称催化,有机合成

课题(ti)组成员(Group Members)

在读研究(jiu)生(Current Members)

博士(shi)研究生: 暂无

硕士研究生(sheng): 2017级: 漆(qi)玲(Ling Qi),秦海林(Hai-Lin Qin),李(li)龙(long)宣(Long-Xuan Li)

2018级: 陈中菊(Zhong-Ju Chen),朱国(guo)胜(sheng)(Guo-Sheng Zhu)

2019级: 王利亮(Li-Liang Wang),郭(guo)明芳(Ming-Fang Guo),杨铭(Ming Yang)

已毕(bi)业研(yan)究生(Past Members,就业信(xin)息更新至201812月(yue))

博士研究生(sheng): 2016级: 杨培俊(Pei-Jun Yang,本科毕业于(yu)合(he)肥(fei)师范学院,安(an)徽工(gong)程大学生(sheng)物与化(hua)工(gong)学院专(zhuan)任(ren)教师)。

硕(shuo)士研究生: 2016级(ji): 汪阳(Yang Wang,本科毕业于(yu)淮(huai)北(bei)师范(fan)大学),就职(zhi)于(yu)南(nan)京梯尔希(xi)医药(yao)有限公(gong)(gong)司;刘丙义(Bing-Yi Liu,本科毕业于(yu)滁州(zhou)学院),就职(zhi)于(yu)南(nan)京梯尔希(xi)医药(yao)有限公(gong)(gong)司。

2015级: 张虎(Hu Zhang,王(wang)绍武教授共(gong)同指导,本科毕业于(yu)宿州学院(yuan)),就职(zhi)于(yu)温州瑞浦能源(yuan)有(you)限公司

2014级: 刘珍(Zhen Liu,杨高升教授共(gong)同指导,本科毕业于(yu)阜阳(yang)师范学(xue)院)

2013级: 杨(yang)培俊(Pei-Jun Yang,杨(yang)高升教(jiao)授共同指导(dao),本科毕(bi)业于(yu)合肥师(shi)范学院)

2012级: 朱(zhu)佑民(min)(You-Min Zhu,王绍武教(jiao)授共(gong)同指导,本(ben)科毕(bi)业(ye)于(yu)淮(huai)海(hai)工(gong)学院),就职于(yu)北京创腾科技有限公司;陈加男(Jia-Nan Chen,杨高升(sheng)教(jiao)授共(gong)同指导,本(ben)科毕(bi)业(ye)于(yu)阜阳师(shi)范学院),就职于(yu)南京海(hai)纳(na)医药(yao)有限公司

2011级: 王彪(Biao Wang,杨(yang)高升教授共同指导,本科毕业于(yu)安徽师范大学(xue)),就职于(yu)南(nan)京(jing)华威医(yi)药有限公(gong)司。

已发表(biao)论(lun)文(Publications

2018–2019年(nian)

23. Yang Wang, Bing-Yi Liu, Gaosheng Yang, Zhuo Chai,* “Synthesis of 2-Aminophosphates via SN2-Type Ring Openings of Aziridines with Organophosphoric Acids”, Org. Lett. 2019, 21, 44754479.

22. Pei-Jun Yang, Ling Qi, Zhen Liu, Gaosheng Yang, Zhuo Chai,* “Lewis Acid-Catalyzed Dynamic Kinetic Asymmetric Transformation of Racemic N-Sulfonylaziridines”, J. Am. Chem. Soc. 2018, 140, 1721117217.

2017

21. Zhuo Chai, Yemei Wang, Mujun Tang, Xiaolong Mu, Jinsong Hou, Gaosheng Yang,* “Chiral rare-earth metal complexes with a tridentate amido-fluorenyl ligand: Syntheses, structures and catalytic performance”, J. Organomet. Chem. 2017,846, 236241. 

20. Deju Hua, Pengfei Yang, Yue Shen, Gaosheng Yang,* Zhuo Chai,* “PCl5-mediated ring-openings of trans-2,3-disubstituted cyclopropane-1,1-diesters: a stereoselective way to trisubstituted vinyl cholorides”, Tetrahedron 2017, 73, 1205–1210.

19. Zhuo Chai, Jiang Chu, Yunyi Qi, Mujun Tang, Jinsong Hou and Gaosheng Yang,* “Half-sandwich chiral rare-earth metal complexes with linked tridentate amido-indenyl ligand: synthesis, characterization, and catalytic properties for intramolecular hydroamination”, RSC Adv., 2017, 7, 1759–1765.

18. Zhuo Chai,* Pei-Jun Yang, Hu Zhang, Shaowu Wang, Gaosheng Yang, “Synthesis of Chiral Vicinal Diamines by Silver(I)-Catalyzed Enantioselective Aminolysis ofN-Tosylaziridines”, Angew. Chem. Int. Ed. 2017, 56, 650654 (highlighted in Synfacts, 2017, 396).

2015–2016

17. Zhuo Chai,* Jia-Nan Chen, Zhen Liu, Xue-Fei Li, Pei-Jun Yang, Ji-Ping Hu, Gaosheng Yang, “[3+2]-Annulations of N-alkyl-3-substituted indoles with quinone monoketals catalysed by Br?nsted acids”, Org. Biomol. Chem. 2016, 14, 10241030.

16. Zhuo Chai,* You-Min Zhu, Pei-Jun Yang, Shaoyin Wang, Shaowu Wang,* Zhen Liu, Gaosheng Yang, “Copper(I)-Catalyzed Kinetic Resolution of N-Sulfonylaziridines with Indoles: Efficient Construction of Pyrroloindolines”, J. Am. Chem. Soc. 2015, 137, 1008810091 (highlighted by X-MOL: http://www.x-mol.com/news/5199).

15. Gaosheng Yang,* Tingting Wang, Jun Chai, Zhuo Chai,* “AlCl3-Catalyzed [3+2] Annulations of cis-2,3-Disubstituted Cyclopropane 1,1-Diesters with Cyclic Ketones: Diastereoselective Construction of Spirotetrahydrofurans”, Eur. J. Org. Chem. 2015, 10401046.

2014

14. Zhuo Chai, Dezhi Hua, Kui Li, Jiang Chu, Gaosheng Yang,* “A novel chiral yttrium complex with a tridentate linked amido-indenyl ligand for intramolecular hydroamination”, Chem. Commun. 2014, 50, 177179.

13. Zhuo Chai,* Biao Wang, Jia-Nan Chen, Gaosheng Yang, “Arylation of Azlactones using Diaryliodonium Bromides and Silver Carbonate: Facile Access to alpha-Tetrasubstituted Amino Acid Derivatives”, Adv. Synth. Catal. 2014,356, 27142718.

12. Zhuo Chai, Dezhi Hua, Kui Li, Jiang Chu, Gaosheng Yang,* “Rare-earth metal complexes with tridentate linked amido-indenyl ligand: Synthesis, characterization, and catalytic properties for intramolecular hydroamination”, J. Organomet. Chem. 2014, 768, 136139.

11. Shaoyin Wang, Xiancui Zhu, Zhuo Chai,* and Shaowu Wang,* “Synthesis of polysubstituted pyrroles via [3+2]-annulation of aziridines and beta-nitroalkenes under aerobic conditions”, Org. Biomol. Chem. 2014, 12, 13511356.

2013

10. Yongxian Sun, Gaosheng Yang,* Zhuo Chai,* Xiaolong Mu, Jun Chai, AlCl3-promoted [3+2] annulation of cis-2,3-disubstituted cyclopropane 1,1-diesters with isothiocyanates: stereoselective synthesis of densely substituted 2-iminodihydrothiophenes”, Org. Biomol. Chem. 2013, 11, 78597868.

9. Yongxian Sun, Gaosheng Yang,* Yue Shen, Hua Zan, Zhuo Chai,* “Stereoselective cyclopropanation of a-bromochalcone with diethyl malonate promoted by K2CO3”, Tetrahedron 2013, 69, 51045111.

8. Gaosheng Yang,* Yongxian Sun, Yue Shen, Zhuo Chai,* Shuangliu Zhou, Jiang Chu, Jun Chai, “cis-2,3-Disubstituted Cyclopropane 1,1-Diesters in [3+2] Annulations with Aldehydes: Highly Diastereoselective Construction of Densely Substituted Tetrahydrofurans”, J. Org. Chem. 2013, 78, 53935400.

7. Zhuo Chai, Jean-Philippe Bouillon, Dominique Cahard,* “Chiral Br?nsted Acid-Catalyzed Diastereo- and Enantioselective Synthesis of CF3-Substituted Aziridines”, Chem. Commun. 2012, 48, 9471–9473.

6. Zhuo Chai, Trevor J. Rainey,* “Pd(II)/Br?nsted Acid Catalyzed Enantioselective Allylic C-H Activation for the Synthesis of Spirocyclic Rings”,J. Am. Chem. Soc. 2012, 134, 3615–3618.

5. Zhuo Chai, Gang Zhao,* “Efficient Organocatalysts Derived From Simple Chiral Acyclic Amino Acids in Asymmetric Synthesis” Catal. Sci. Technol. 2012, 2, 29–41.

4. Zhuo Chai, Hai-Feng Wang, Gang Zhao,* “Ni-Catalyzed Carbocyclization of 1,6-Enynes Mediated by Dialkylzinc Reagents: Me2Zn or Et2Zn Makes a Difference”, Synlett 2009, 17851790.

3. Zhuo Chai, Zheng-Feng Xie, Xin-Yuan Liu, Ji-De Wang*, Gang Zhao*, “Tandem Addition/Cyclization Reaction of Organozinc Reagents to 2-Alkynyl Aldehydes: Highly Efficient Regio- and Enantioselective Synthesis of 1,3-Dihydroisobenzofurans and Tetrasubstituted Furans”, J. Org. Chem. 2008, 73, 29472950 (highlighted in Synfacts, 2008, 712).

2. Zhuo Chai, Xin-Yuan Liu, Jun-Kang Zhang, Gang Zhao*, “Enantioselective Addition of Alkenylzinc Reagents to Aldehydes With Organoboronates as the Alkenyl Source”, Tetrahedron: Asymmetry 2007, 18, 724728.

1. Zhuo Chai, Xin-Yuan Liu, Xiao-Yu Wu, Gang Zhao*, “Synthesis of Modular Thiophene-Oxazoline Ligands and Their Application in the Asymmetric Phenyl Transfer Reaction to Aldehydes”, Tetrahedron: Asymmetry 2006, 17, 24422447.

会议(yi)报告

  1. 第十三届江淮有机化学论坛,青年学者报(bao)告(gao),“Copper(I)-Catalyzed Enantioselective [3+2] Annulation of Indoles and N-Sulfonylaziridines”,会议时间: 2015年(nian)1030日至111日(ri),南(nan)京(jing)大学(xue)(江苏南(nan)京(jing))。

  2. 第十(shi)四届全国有机合(he)成化学学术研(yan)讨会,口头报告,“路(lu)易斯酸催化外消旋吖丙(bing)啶不对称开环(huan)反(fan)应研(yan)究”,会议时间(jian): 20171026日(ri)至10月(yue)29日,淮北师(shi)范大学(安(an)徽淮北)。

  3. 第十届全国(guo)有机化(hua)学学术年会,口头报告,“路(lu)易斯(si)酸催化(hua)外(wai)消旋吖丙啶的立体(ti)汇(hui)聚(ju)式(shi)转化(hua)反(fan)应研究(jiu)”,会议时间: 2017年(nian)1218日至(zhi)1221日,南方科技大学(广东深圳)。

  4. 中(zhong)(zhong)国化学会手性(xing)中(zhong)(zhong)国2019学术(shu)研(yan)讨(tao)会,口头报告,“外消(xiao)旋吖丙啶的不对称催化转化反应研(yan)究”,会议时间: 2019112日至(zhi)113日,南方(fang)科技大学(广东(dong)深(shen)圳(zhen))。

  5. 第十六届全国有机合成化学(xue)学(xue)术研讨会,邀请(qing)报告,“路易(yi)斯酸催(cui)化外消旋吖丙(bing)啶(ding)的不对(dui)称(cheng)转化反应研究”,会议时间: 20198月(yue)8日至811日,河(he)南(nan)大学(河(he)南(nan)开封)。

教学研(yan)究论文

柴卓(zhuo),“有机反应(ying)立体(ti)选(xuan)择性描述术语 % ee/er% de/dr刍(chu)议”,大学化学20173260–62.

专(zhuan)

柴卓,杨高升,李奎,华德智,“一种稀土配合物催化剂,其制备方(fang)法(fa)、用途以及应用方(fang)法(fa)”,中国(guo)发明专利, 专利号: ZL 2013 1 0394971.4.

柴卓,朱(zhu)佑民(min),王绍武,杨(yang)培俊,杨(yang)高(gao)升,“一种手性六氢吡咯并吲哚类(lei)化合物的(de)制备方法(fa)”,中国发明专(zhuan)利, 专利号: ZL 2015 1 0262771.2.

柴卓,杨(yang)培俊,王绍(shao)武,杨(yang)高升,“一种手(shou)性邻二胺类(lei)化合物(wu)及其(qi)制备方(fang)法(fa)”,中国发明专利, 专(zhuan)利号(hao): ZL 2016 1 0234895.4.

柴卓(zhuo),杨培俊,杨高(gao)升,“一种手性噁唑烷类化合物(wu)及其制备(bei)方法”,中国发明(ming)专利, 申请号: CN****10761427.7.

Gang Zhao*, Zhuo Chai, Chapter 3: Insoluble Resin-supported Catalysts in Recoverable and Recyclable Catalysts, Benaglia, M. Eds.; John Wiely & Sons: Chichester, 2009, Chapter 3, pp 49-72.

 

 


编辑: 柴(chai)卓   |   更新日期: 2018-12-17   |   点击: 19346
 


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